As per a new study, scientists have developed a vaccine candidate for COVID-19 that creates “extremely high levels” of protective antibodies in animal models, it is an advance that might lead to a new therapeutic to cure the pandemic.
According to the study of researchers, from the University of Washington (UW) School of Medicine in the US, the nanoparticle vaccine produces virus-neutralizing antibodies in mice at levels much higher than is witnessed in people who have cured of the virus.
The research, released in the journal Cell, stated that it generates ten times more neutralizing antibodies in mice, even at a six-fold lower vaccine dose, and also signs a strong B-cell immune response after administration, which can be critical for a long-lasting vaccine effect.
As per the report, when a single nonhuman primate was immunized with the vaccine, the scientists said the candidate therapeutic produced neutralizing antibodies targeting multiple different sites on the spike protein of the coronavirus, which it uses to enter human cells. They said this may ensure protection against mutated strains of the virus, should they arise.
Neil King, a co-author of the study from UW Medicine said, “We hope that our nanoparticle platform may help fight this pandemic that is causing so much damage to our world. The potency, stability, and manufacturability of this vaccine candidate differentiate it from many others under investigation.”